Bilateral renal denervation reduced atherosclerosis progression in apolipoprotein E-deficient mice compared with sham operation (4.2% vs 6.3%; P<0.05), independent of blood pressure lowering.
Does bilateral renal denervation reduce progression of atherosclerosis in apolipoprotein E-deficient mice?
Bilateral renal denervation attenuates the progression of atherosclerosis in apolipoprotein E-deficient mice independently of blood pressure lowering, associated with reduced aldosterone, MCP-1, and oxidative stress.
Absolute Event Rate: 4.2% vs 6.3%
p-value: p=<0.05
The renal autonomic nervous system may contribute to hypertension and vascular disease. Although the effects of renal artery denervation on blood pressure lowering are controversial, there may be other beneficial vascular effects independent of blood pressure lowering. Bilateral renal denervation (RDN) or sham operation (SO) was performed in 14-week-old male apolipoprotein E-deficient mice on a Western diet starting at 10 weeks of age. Efficacy of RDN was confirmed by reduction of renal norepinephrine levels (SO: 3.8±0.1 versus RDN: 1.7±0.3 ng/mL; P<0.01) at 6 weeks after procedure. Compared with SO, RDN had no effect on blood pressure (SO: 101.0±2.4 versus RDN: 97.5±1.6 mm Hg; P=0.25), total cholesterol (SO: 536.7±28.5 versus RDN: 535.7±62.9 mg/dL; P=0.99), or triglycerides (SO: 83.7±3.5 versus RDN: 86.9±10.2 mg/dL; P=0.78). Quantification of atherosclerosis at 20 weeks of age demonstrated reduced atherosclerosis in mice receiving RDN compared with SO (arterial tree oil-red-O surface staining RDN: 4.2±0.5% versus SO: 6.3±0.7%; P<0.05). Reduced atherosclerosis was associated with increased smooth muscle cell content in atherosclerotic plaques (RDN: 13.3±2.1 versus SO: 8.1±0.6%; P<0.05). Serum levels of aldosterone, monocyte chemoattractant protein-1, and 8-isoprostane were lower in mice that received RDN compared with sham-operated mice (aldosterone; RDN: 206.8±33.2 versus SO: 405.5±59.4 pg/mL, P<0.05; monocyte chemoattractant protein-1; RDN: 51.7±7.9 versus SO: 91.71±4.6 pg/mL, P<0.05; 8-isoprostane; RDN: 331.9±38.2 versus SO: 468.5±42.0 pg/mL, P<0.05). RDN reduces progression of atherosclerosis in apolipoprotein E-deficient mice. These changes are associated with reduced aldosterone levels, monocyte chemoattractant protein-1, and markers of oxidative stress.
Wang et al. (Tue,) conducted a other in Atherosclerosis. Bilateral renal denervation (RDN) vs. Sham operation (SO) was evaluated on Atherosclerosis quantification (arterial tree oil-red-O surface staining) (p=<0.05). Bilateral renal denervation reduced atherosclerosis progression in apolipoprotein E-deficient mice compared with sham operation (4.2% vs 6.3%; P<0.05), independent of blood pressure lowering.
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