Impaired oxygen pulse recovery during exercise testing was associated with a significantly reduced peak cardiac output (e.g., 8.0 vs 11.0 L/min) in patients with chronic heart failure.
Observational (n=61)
Is impaired oxygen pulse recovery associated with a reduced cardiac output response to exercise in patients with chronic heart failure?
Impaired oxygen pulse recovery during cardiopulmonary exercise testing is associated with a reduced cardiac output response and worse functional status in patients with chronic heart failure.
Effect estimate: r = 0.57
Abstract Purpose The cardiac output (CO) response to exercise is a useful marker to grade the prognosis and severity of chronic heart failure (CHF). The recovery of the oxygen pulse (OP) is a non‐invasive parameter, which is related to exercise capacity in cardiac patients. However, the relation between OP recovery and the central haemodynamic response to exercise remains to be determined. We hypothesized that an impaired OP recovery is associated with a reduced CO response to exercise in CHF patients. Methods Sixty one CHF patients performed cardiopulmonary exercise test with simultaneous measurement of CO. Impaired OP recovery was defined as an overshoot during the first minute of recovery or OP at 1‐min recovery as a percentage of peak OP (OP RR ). Results An OP overshoot was observed in 9% ( n = 5) of patients. In these patients, peak CO and VO 2 were significantly lower (peak CO 7.9 ± 0.8 versus 11.2 ± 4.3 L/min and peak VO 2 14.1 ± 4.7 versus 19.6 ± 5.8 ml min −1 kg −1 ). Mean relative recovery of OP was 78 ± 20%. Slow OP recovery (negative OP RR ) was seen in 13% ( n = 8). Peak CO and VO 2 were significantly lower in the negative OP RR group (11 ± 4 versus 8 ± 0.7 L/min and 19.7 ± 5.9 versus 14.6 ± 3.7 ml kg min −1 ). There was a significant relation between OP RR and stroke volume (SV) RR ( r = .57), as well as between OP RR and a‐v O 2 diff RR ( r s = .4). Conclusion An impaired OP recovery is associated with a reduced CO response to exercise and worse functional status. Therefore, the OP recovery can be used to grade the severity of CHF.
Spee et al. (2020) conducted an observational in Chronic heart failure (n=61). Oxygen pulse recovery assessment vs. Normal oxygen pulse recovery was evaluated on Cardiac output response to exercise (r = 0.57). Impaired oxygen pulse recovery during exercise testing was associated with a significantly reduced peak cardiac output (e.g., 8.0 vs 11.0 L/min) in patients with chronic heart failure.