Higher levels of the inflammatory marker PIV (1832 vs 355.9, p<0.001) were significantly associated with atrial fibrillation recurrence at one year following cryoballoon ablation.
Observational (n=157)
Do elevated inflammatory markers, specifically PIV, predict atrial fibrillation recurrence in patients treated with cryo balloon ablation?
Elevated inflammatory markers, particularly the pan-immune-inflammation value (PIV), are strongly associated with atrial fibrillation recurrence within one year after cryoballoon ablation.
p-value: p=<0.001
AIM/BACKGROUND: Although atrial fibrillation is the most common rhythm problem, the results of treatment to restore sinus rhythm are still not satisfactory. Nearly half of patients undergoing ablation relapse within one year. Therefore, triggered activities may not be the only cause. Inflammation is quite common in AF. In this study, we investigated the effect of PIV, an inflammatory marker, on recurrence. METHODS: A total of 157 patients who underwent ablation with cryo balloon were included in the study. One-year follow-up was evaluated for causes of recurrence. RESULTS: When the inflammatory parameters between the two groups are analyzed, CRP (5.9 5.0-6.9 vs 9.7 7.6-11.9, p < 0.001), NL ratio (2.8 2.5-3.0 vs 6.4 5.0-6.8, p < 0.001), SII2 (618.5 557.1-679.9 vs 1798.9 1305.8-2292.1, p < 0.001), PIV (355.9 313.4-398.4 vs 1832 1317.8-2347.1, p < 001) were significantly higher in the AF recurrence group. ROC analysis showed that PIV had the best sensitivity and specificity. CONCLUSIONS: Inflammation has been found to be a cause of AF recurrence and PIV is one of the best markers for this.
Elçik et al. (2025) conducted an observational in Atrial fibrillation (n=157). PIV (inflammatory marker) was evaluated on Atrial fibrillation recurrence (p=<0.001). Higher levels of the inflammatory marker PIV (1832 vs 355.9, p<0.001) were significantly associated with atrial fibrillation recurrence at one year following cryoballoon ablation.