Sporadic bilateral hyperaldosteronism is frequently driven by aldosterone-producing micronodules harboring somatic mutations, alongside rare germline variants and paracrine activation.
Recent research has identified aldosterone-producing micronodules, somatic mutations, and new genetic variants as key drivers in the molecular pathogenesis of bilateral primary aldosteronism.
PURPOSE OF REVIEW: Renin-independent aldosterone production from one or both affected adrenal(s), a condition known as primary aldosteronism (PA), is a common cause of secondary hypertension. In this review, we aimed to summarize recent findings regarding pathophysiology of bilateral forms of PA, including sporadic bilateral hyperaldosteronism (BHA) and rare familial hyperaldosteronism. RECENT FINDINGS: The presence of subcapsular aldosterone synthase (CYP11B2)-expressing aldosterone-producing micronodules, also called aldosterone-producing cell clusters, appears to be a common histologic feature of adrenals with sporadic BHA. Aldosterone-producing micronodules frequently harbor aldosterone-driver somatic mutations. Other potential factors leading to sporadic BHA include rare disease-predisposing germline variants, circulating angiotensin II type 1 receptor autoantibodies, and paracrine activation of aldosterone production by adrenal mast cells. The application of whole exome sequencing has also identified new genes that cause inherited familial forms of PA. SUMMARY: Research over the past 10 years has significantly improved our understanding of the molecular pathogenesis of bilateral PA. Based on the improved understanding of BHA, future studies should have the ability to develop more personalized treatment options and advanced diagnostic tools for patients with PA.
Nanba et al. (Fri,) conducted a review in Bilateral hyperaldosteronism (Primary aldosteronism). Sporadic bilateral hyperaldosteronism is frequently driven by aldosterone-producing micronodules harboring somatic mutations, alongside rare germline variants and paracrine activation.
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