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Histologic material from 75 cases of uterine cervical cancer was studied with particular emphasis on the morphology of the regional lymph nodes. Sixty-seven cases were squamous cell and eight were adenocarcinomas. Sixteen were metastatic and 59 non-metastatic. Five-year survival data were available in 42 cases. We found that lymph nodes could be classified in four distinct histologic patterns which we designated “lymphocyte predominance,” “germinal center predominance,” “lymphocyte depletion,” and “unstimulated.” Correlation of the histologic pattern with the presence or absence of metastasis and the survival data demonstrated that lymphocyte predominance was common in non-metastatic cases and in cases with high survival rate. The “lymphocyte depletion” pattern was common in metastatic cases and in cases with low survival rate. The “germinal center predominance” pattern was associated with an intermediate survival rate. The possible relationship of these patterns to host cell-mediated and humoral immune responses is discussed.
Tsakraklides et al. (Sun,) studied this question.
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