Experimental uremia in rats with myocardial infarction led to progressive impairment of left ventricular ejection fraction (decreasing to 51% vs ~70% in controls at 8 weeks) and accelerated remodeling.
Does experimental uremia aggravate left ventricular remodeling and function after myocardial infarction in rats?
Experimental uremia accelerates left ventricular remodeling, progressive impairment of LV function, and myocardial fibrosis following myocardial infarction.
Absolute Event Rate: 51% vs 70%
BACKGROUND: Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations. METHODS: Subtotally nephrectomized rats (SNX) and controls with MI only (MIC) were examined 1, 4 and 8 weeks after MI. MI size, ejection fraction (EF), cardiac fibrosis, vascular density and cardiomyocyte density were studied. RESULTS: The extension of MI was 0.08 +/- 0.02 in SNX versus 0.06 +/- 0.02 in MIC rats (p < 0.031). Prior to MI, EF was comparable in SNX and MIC (74 +/- 3 vs. 72 +/- 2%, n.s.). Despite a relatively small infarct size EF in SNX decreased to 58 +/- 4% 1 week after infarction and progressively worsened to 51 +/- 4% after 8 weeks. In MIC animals EF only slightly decreased 1 week after MI (70 +/- 3%) and remained unchanged at follow-up. In SNX animals LV end-diastolic diameter continuously increased following MI throughout the study period indicating accelerated remodeling. Furthermore, accelerated myocardial fibrosis was already notable 1 week after MI in SNX animals and the volume density of capillaries and cardiomyocytes was significantly lower in SNX rats. CONCLUSION: MI in experimental uremia is associated with progressive impairment of LV function, LV dilatation and accelerated myocardial fibrosis.
Dikow et al. (Fri,) conducted a other in Myocardial infarction and uremia. Subtotal nephrectomy (experimental uremia) vs. MI only controls was evaluated on Ejection fraction at 8 weeks. Experimental uremia in rats with myocardial infarction led to progressive impairment of left ventricular ejection fraction (decreasing to 51% vs ~70% in controls at 8 weeks) and accelerated remodeling.