Higher fasting serum adiponectin levels were significantly correlated with better endothelial function, as measured by the vascular reactivity index (β = 0.574), in patients with coronary artery disease.
Cross-Sectional (n=125)
Are serum adiponectin levels associated with endothelial function measured by vascular reactivity index in patients with coronary artery disease?
Higher fasting serum adiponectin levels are independently associated with better endothelial function in patients with coronary artery disease.
Effect estimate: β = 0.574
Objectives: Adiponectin has anti-inflammatory and antiatherogenic effects and is important in the pathogenesis of cardiovascular diseases. In this cross-sectional study, our objective was to study the potential correlation between serum adiponectin levels and endothelial function in participants with coronary artery disease (CAD). Materials and Methods: We collected serum specimens from 125 fasting participants with CAD. The endothelial function was measured using the vascular reactivity index (VRI) determined by digital thermal monitoring, and VRI values of >2.0, 1.0-1.9, and <1.0 indicated good, intermediate, and poor vascular reactivity, respectively. A commercially available enzyme immunoassay kit was used to measure serum adiponectin levels. Results: The cohort included 55, 57, and 13 patients with good, intermediate, and poor vascular reactivity, respectively. Poor vascular reactivity was shown to be associated with older age, higher levels of serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), C-reactive protein, and lower levels of serum albumin and adiponectin. The linear regression analysis with multivariable forward stepwise approach revealed that age (β = -0.232), serum LDL-C (β = -0.264), and serum adiponectin (β = 0.574) were correlated with the VRI in CAD patients significantly. Conclusion: Fasting serum adiponectin levels were associated with good endothelial function determined using the VRI in patients with CAD.
Hsiao et al. (Thu,) conducted a cross-sectional in coronary artery disease (CAD) (n=125). Serum adiponectin levels was evaluated on Correlation between serum adiponectin levels and endothelial function (vascular reactivity index) (β = 0.574). Higher fasting serum adiponectin levels were significantly correlated with better endothelial function, as measured by the vascular reactivity index (β = 0.574), in patients with coronary artery disease.