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This research investigates how temperature affects the behavior of immune cells and tissue regeneration in zebrafish.

May 29, 2026Open Access

In vivo imaging reveals temperature sensitivity of innate immune cell behavior and tissue regeneration in zebrafish

Key Points

This research investigates how temperature affects the behavior of immune cells and tissue regeneration in zebrafish.
In vivo imaging was utilized to observe immune cell recruitment across five different temperatures.
Neutrophil and macrophage responses were measured to determine their association with varying thermal conditions.
The impact of temperature on tail regeneration was also analyzed.
Neutrophil recruitment increased steadily with higher temperatures.
Macrophage recruitment peaked at around 31°C, indicating a narrow optimal thermal window.
Excessively high temperatures were shown to disrupt immune resolution and the regeneration of tissue.

Abstract

• In vivo imaging quantifies immune cell recruitment across five temperatures. • Neutrophil recruitment increases steadily with warming. • Macrophage recruitment peaks within a narrow thermal window near 31°C. • Tail regeneration follows a similar thermal optimum as macrophage recruitment. • High temperatures disrupt immune resolution and tissue repair.

In vivo imaging reveals temperature sensitivity of innate immune cell behavior and tissue regeneration in zebrafish

Key Points

Abstract

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