What does this research mean for the field?

In patients receiving CAR-T therapy, female sex is associated with lower odds of treatment response, while public insurance is associated with an increased risk of severe neurotoxicity and ICU admission. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to investigate the impact of sociodemographic factors on CAR-T therapy outcomes, including treatment response and toxicity.

May 30, 2026Journal of Clinical Oncology

Sociodemographic disparities and clinical outcomes in chimeric antigen receptor (CAR) T-cell therapy: A real-world study at a diverse academic cancer center.

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Authors

ZOZara Orozco OAOmer S. Ashruf

Discussion

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Overview

Retrospective cohort study evaluates CAR-T therapy outcomes, emphasizing sociodemographic disparities in patients.

Key Points

This study aims to investigate the impact of sociodemographic factors on CAR-T therapy outcomes, including treatment response and toxicity.
Retrospective cohort study of 101 adult patients receiving CAR-T therapy at USC Norris Comprehensive Cancer Center from 2022-2025.
Collected demographic, geographic, clinical, and treatment-related variables from REDCap.
Analyzed data using multivariable logistic regression and chi-square/Fisher’s exact tests.
Female patients had significantly lower odds of achieving a treatment response compared to males (OR 6.69 for males, p = 0.038).
Public insurance was linked to a higher risk of severe neurotoxicity (ICANS grade ≥3, p = 0.012) and increased ICU admissions (p = 0.035).
Diagnosis of DLBCL was associated with reduced odds of treatment response (p < 0.05).

Cite This Study

Orozco et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80270307b78509432323 https://doi.org/10.1200/jco.2026.44.16_suppl.e23435

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May 30, 2026Journal of Clinical Oncology

Sociodemographic disparities and clinical outcomes in chimeric antigen receptor (CAR) T-cell therapy: A real-world study at a diverse academic cancer center.

View Full Paper

Ask AI

Bookmark

Authors

ZOZara Orozco OAOmer S. Ashruf

Discussion

Member takes

Overview

Retrospective cohort study evaluates CAR-T therapy outcomes, emphasizing sociodemographic disparities in patients.

Key Points

This study aims to investigate the impact of sociodemographic factors on CAR-T therapy outcomes, including treatment response and toxicity.
Retrospective cohort study of 101 adult patients receiving CAR-T therapy at USC Norris Comprehensive Cancer Center from 2022-2025.
Collected demographic, geographic, clinical, and treatment-related variables from REDCap.
Analyzed data using multivariable logistic regression and chi-square/Fisher’s exact tests.
Female patients had significantly lower odds of achieving a treatment response compared to males (OR 6.69 for males, p = 0.038).
Public insurance was linked to a higher risk of severe neurotoxicity (ICANS grade ≥3, p = 0.012) and increased ICU admissions (p = 0.035).
Diagnosis of DLBCL was associated with reduced odds of treatment response (p < 0.05).

Cite This Study

Orozco et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80270307b78509432323 https://doi.org/10.1200/jco.2026.44.16_suppl.e23435

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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