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May 30, 2026Journal of Clinical Oncology

Rural-urban disparities in demographics, clinical characteristics, and hospitalization burden among young non-smoking adults with lung cancer in the United States.

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Authors

RSRahul SinglaARAishwarya RameshFAFathima Shehnaz Ayoobkhan

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Overview

Randomized trial reveals demographic differences in hospitalization burdens among young non-smokers with lung cancer, suggesting gaps in resources.

Key Points

  • Investigate rural-urban disparities in demographics and hospitalization burden among young non-smoking lung cancer patients.
  • Analyzed hospitalization data from National Inpatient Sample (2016-2022) for young adults aged 18-50 with lung cancer.
  • Compared demographics and hospitalization burden of non-smokers treated at rural versus urban hospitals.
  • Adjusted hospital charges for inflation using survey weighting methodology.
  • Only 4.07% of non-smokers were treated at rural centers (n=1,570) compared to urban centers (n=36,965).
  • Rural patients showed higher rates of diabetes (19.43% vs 12.50%, p=0.0007) and nearly four-fold increased suicidality (1.91% vs 0.51%, p=0.0013).
  • Rural hospitalizations were significantly shorter (4.76 vs 6.96 days, p<0.001) with lower charges ($45,300 vs $112,080, p<0.001).

Cite This Study

Singla et al. (2026) studied this question.

synapsesocial.com/papers/6a1a80de0307b78509432c16https://doi.org/10.1200/jco.2026.44.16_suppl.e20645
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C31-03 Rural-urban Trends in Tobacco Use, Lung Cancer Screening, and Smoking Cessation2026
  2. 2A105-23 Lung Cancer: Outcomes in Rural Populations2026
  3. 3Disparities in Lung Cancer Health Outcomes and Access to Lung Cancer Screening Between Rural and Urban Areas in the U.S2026
  4. 4Lung Cancer Disparities in the United States: The Role of Smoking, Comorbidities, Socioeconomic Status, and Regional Variation2026
  5. 5Abstract 5045: Patterns of tobacco use, cessation interventions, and lung cancer screening in rural vs. urban areas over time; a 10-year retrospective cohort study2026