T1 preparation MRI under constant gadopentetate dimeglumine infusion demonstrated microvascular obstruction as a positive contrast with smaller T1 reduction compared to DHE regions (P<0.0001).
Does a T1 and T2 preparation pulse sequence MRI evaluate microvascular obstruction in a porcine model of reperfused AMI?
T1 preparation under constant Gd-DTPA infusion demonstrates microvascular obstruction as a positive contrast with larger T1 values in a porcine model of reperfused AMI.
p-value: p=<0.0001
PURPOSE: To investigate a T1 and T2 preparation pulse sequence to evaluate microvascular obstruction (MO) in a porcine model of reperfused acute myocardial infarction (AMI). MATERIALS AND METHODS: A total of 14 pigs with reperfused AMI underwent MRI examinations at baseline and three to four hours after reperfusion. MRI scans included a left ventricular functional study, T1 and T2 measurement on a 1.5T MRI system. At reperfusion, first-pass myocardial perfusion (FPMP) images were obtained after bolus injection of gadopentetate dimeglumine followed by an intravenous drip. Delayed contrast-enhanced MRI (DE-MRI) and T1 measurements were performed 30 and 45 minutes, respectively, after the bolus, during a constant infusion of gadopentetate dimeglumine. RESULTS: In 11 pigs MO was hypoenhanced in FPMP and DE-MRI. In later T1 preparation difference images postcontrast, MO was hyperenhanced while delayed hyperenhanced (DHE) regions appeared dark. MO areas on DE-MRI and T1 images were comparable. T1 reduction (%) postcontrast in MO was small compared to measurements from DHE regions (P < 0.0001) and similar to those from control segments (P = 0.66). Precontrast T1 and T2 values at reperfusion from MO and DHE regions were larger than in control regions. CONCLUSION: Using T1 preparation under a constant gadopentetate dimeglumine (Gd-DTPA) infusion, delayed imaging at 30 to 45 minutes demonstrates MO as a positive contrast with larger T1 values. Elevated T1 and T2 values in MO precontrast may also help to differentiate them from both control and DHE regions.
Yang et al. (Mon,) conducted a other in Reperfused acute myocardial infarction (AMI) (n=14). T1 and T2 preparation pulse sequence MRI with gadopentetate dimeglumine vs. Control segments and delayed hyperenhanced (DHE) regions was evaluated on T1 reduction (%) postcontrast in microvascular obstruction (MO) compared to DHE regions (p=<0.0001). T1 preparation MRI under constant gadopentetate dimeglumine infusion demonstrated microvascular obstruction as a positive contrast with smaller T1 reduction compared to DHE regions (P<0.0001).