Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes After Intensive Statin Treatment

Key Points

• This research investigates the impact of intensive statin therapy on cholesterol efflux and the associated changes in transcriptomes.
• Evaluated cholesterol efflux and transcriptomic profiles after intensive statin treatment.
• Utilized intracoronary imaging techniques for assessment.
• Sample included individuals undergoing intensive statin therapy.
• Intensive statin treatment significantly improved cholesterol efflux capacity (p<0.01).
• Transcriptomic analysis revealed 200 differentially expressed genes related to lipid metabolism (P<0.05).
• Improvements in intracoronary imaging metrics correlated with changes in gene expression profiles.