Melanocytic nevi exhibiting perineuriomatous differentiation are rare and pose significant diagnostic challenges due to their low incidence and morphological resemblance to other cutaneous spindle-cell lesions, including desmoplastic melanoma. In this report, we describe the clinical, dermoscopic, microscopic, and immunohistochemical features of a perineuriomatous melanocytic nevus on the right mid-forearm of a 73-year-old Caucasian man. Given the scarcity of reported cases, documenting additional examples is crucial for refining clinicopathological diagnostic criteria. Accurate identification relies on thorough histopathological and immunohistochemical assessment. By presenting the current case, we aim to enhance diagnostic accuracy and raise awareness of this uncommon nevus. A clearer understanding of these characteristics will help dermatologists and dermatopathologists identify this nevus and distinguish it from other cutaneous spindle-cell proliferations.
Mahmood et al. (Sat,) studied this question.