January 1, 2010Open Access

Quantification of 4D left ventricular blood flow organization in normal and failing hearts

Structured PICO

Does 4D left ventricular blood flow organization differ between normal and failing hearts?

Population

13 subjects: 7 patients with dilated cardiomyopathy (DCM) (mean age 52 ± 14 years, 4 female) and 6 healthy subjects (mean age 58 ± 4 years, 3 female).

Intervention

4D (3D+time) blood flow organization measurement using 3-directional, 3-dimensional cine phase-contrast-MRI

Comparator

Healthy subjects

Outcome

Volume and distribution of separate flow components (direct flow/end-diastolic volume ratio and delayed ejection flow/end-diastolic volume ratio)surrogate

4D flow MRI demonstrates that normal LV blood flow organization is significantly altered in dilated cardiomyopathy, characterized by decreased direct flow and increased delayed ejection flow.

Abstract

To measure the volume and distribution of separate flow components in normal and dysfunctional left ventricles (LV).

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