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March 1, 1987Circulation

Histologic dissection was directly related to the degree of platelet accumulation, with 64 +/- 15 X 10(6) platelets/1 cm in the group with marked dissection and 8.7 +/- 3.7 X 10(6) platelets/1 cm in the group with minimal dissection (p < .05).

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Population

deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis

Design

Preclinical

Follow-up

24 hours

Authors

JWJames R. WilentzTST A SanbornCHChristian C. Haudenschild

Discussion

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Overview

Association between dissection and platelet accumulation in rabbit angioplasty model; leaves open whether antiplatelet strategies mitigate early thrombosis in human PCI.

Structured PICO

P
Population
deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis
I
Intervention
experimental transluminal angioplasty
O
Outcome
time course of 51Cr-labeled platelet accumulation after experimental angioplastysurrogate

In a rabbit model of atherosclerosis, marked platelet accumulation occurs early after transluminal angioplasty and correlates with the extent of vascular dissection.

Cite This Study

Wilentz et al. (1987) studied this question.

synapsesocial.com/papers/6a20da2376382611e5180a13https://doi.org/10.1161/01.cir.75.3.636
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