Most NSAIDs, except naproxen (RR 1.06; 95% CI 0.94-1.20), were associated with an increased risk of acute myocardial infarction compared to nonuse, with RRs up to 1.97 for etoricoxib.
Meta-Analysis
Does the use of individual NSAIDs increase the risk of acute myocardial infarction compared to nonuse?
Most NSAIDs, with the exception of naproxen, are associated with an increased risk of acute myocardial infarction, particularly at high doses or in patients with pre-existing coronary heart disease.
Relative Risk: 1.06 (95% CI 0.94–1.2)
OBJECTIVE: To conduct a systematic review of observational studies on the risk of acute myocardial infarction (AMI) with use of individual nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS: A search of Medline (PubMed) for observational studies published from 1990 to 2011 identified 3829 articles; 31 reported relative risk (RR) of AMI with use of individual NSAIDs versus nonuse of NSAIDs. Information abstracted in a standardized form from 25 publications was used for the meta-analysis on 18 independent study populations. RESULTS: Random-effects RR (95% confidence interval (CI)) was lowest for naproxen 1.06 (0.94–1.20), followed by celecoxib 1.12 (1.00–1.24), ibuprofen 1.14 (0.98–1.31), meloxicam 1.25 (1.04–1.49), rofecoxib 1.34 (1.22–1.48), diclofenac 1.38 (1.26–1.52), indometacin 1.40 (1.21–1.62), etodolac 1.55 (1.16–2.06), and etoricoxib 1.97 (1.35–2.89). Heterogeneity between studies was present. For new users, RRs (95% CIs) were for naproxen, 0.85 (0.73–1.00); ibuprofen, 1.20 (0.97–1.48); celecoxib, 1.23 (1.00–1.52); diclofenac, 1.41 (1.08–1.86); and rofecoxib, 1.43 (1.21–1.66).Except for naproxen, higher risk was generally associated with higher doses, as defined in each study, overall and in patients with prior coronary heart disease. Low and high doses of diclofenac and rofecoxib were associated with high risk of AMI, with dose–response relationship for rofecoxib. In patients with prior coronary heart disease, except for naproxen, duration of use ≤3 months was associated with an increased risk of AMI. CONCLUSIONS: Most frequently NSAIDs used in clinical practice, except naproxen, are associated with an increased risk of AMI at high doses or in persons with diagnosed coronary heart disease. For diclofenac and rofecoxib, the risk was increased at low and high doses.
Varas‐Lorenzo et al. (Thu,) conducted a meta-analysis in Acute myocardial infarction. Individual nonsteroidal anti-inflammatory drugs (NSAIDs) vs. Nonuse of NSAIDs was evaluated on Acute myocardial infarction (AMI) (RR 1.06, 95% CI 0.94-1.20). Most NSAIDs, except naproxen (RR 1.06; 95% CI 0.94-1.20), were associated with an increased risk of acute myocardial infarction compared to nonuse, with RRs up to 1.97 for etoricoxib.