What question did this study set out to answer?

This report aims to highlight the presentation of malignant hyperthermia in a trauma patient, particularly focusing on hemodynamic instability.

June 4, 2026

Probable Malignant Hyperthermia Presenting With Refractory Hypotension in a Young Trauma Patient: A Case Report

Key Points

This report aims to highlight the presentation of malignant hyperthermia in a trauma patient, particularly focusing on hemodynamic instability.
Case report of a 25-year-old trauma patient developing refractory hypotension after anesthetic exposure.
Monitoring included Et co 2 levels and treatment response to dantrolene (Ryanodex).
Refractory hypotension and rising Et co 2 noted despite increased ventilation; hemodynamic instability unresponsive to fluids and vasopressors.
Rapid reversal of symptoms following dantrolene administration, underscoring the effectiveness of early treatment.

Abstract

Malignant hyperthermia (MH) is a rare, life-threatening anesthetic complication caused by dysregulated skeletal muscle calcium homeostasis. We report a 25-year-old trauma patient who developed refractory hypotension with rising Et co 2 despite progressive increases in minute ventilation, followed by hyperthermia, 2.5 hours after exposure to succinylcholine and sevoflurane. Hemodynamic instability was unresponsive to fluids and vasopressors but reversed rapidly after treatment for probable MH with dantrolene (Ryanodex). This case highlights early hemodynamic instability as a prominent manifestation of MH and emphasizes rising Et co 2 despite increased ventilation as a critical diagnostic clue requiring prompt dantrolene administration.

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