Why the study?
The study was conducted to assess the use of antihypertensive combination treatment, both as an initial and subsequent therapeutic step, in a large Italian population.
What are the patterns of initial and subsequent antihypertensive combination treatment in a real-life Italian population?
Population
About 100 000 patients per cohort aged 40 years or older newly treated with antihypertensives in Lombardy
Comparison
Monotherapy vs combinations of two, three, and more than three antihypertensive drugs across 2012, 2015, and 2018 cohorts
Design
Database-based cohort study
Follow-up
3 years
Authors
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Low real-world adoption of initial combination antihypertensive therapy persists; leaves open barriers to guideline implementation in hypertension care.
What are the patterns of initial and subsequent antihypertensive combination treatment in a real-life Italian population?
Real-world use of antihypertensive combination therapy remains low and has not increased over the last decade, indicating a gap between clinical practice and guideline recommendations.
Savaré et al. (2022) studied this question.