Black race was independently associated with 1.5-fold higher odds of significant carotid intima media thickness and 50% lower odds of significant coronary artery calcium compared to White race.
Cross-Sectional (n=1,245)
Does Black race compared to White race associate with differences in the burden of CIMT and CAC?
Black race is independently associated with greater carotid intima media thickness but less coronary artery calcium compared to White race, suggesting that cardiovascular risk stratification strategies incorporating subclinical atherosclerosis should consider race-specific algorithms.
Odds Ratio: 0.5 (95% CI 0.3–0.7)
BACKGROUND: Identification of racial differences in the burden and correlates of carotid intima media thickness (CIMT) and coronary artery calcium (CAC) may provide the basis for the development of race-specific cardiovascular disease (CVD) risk prediction algorithms. METHODS: In the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, CIMT was measured by carotid ultrasonography in 792 individuals (35 % Black). CIMT >1 mm was considered significant. CAC was quantified by electron beam computed tomography in 776 individuals (46 % Black). CAC was considered significant if the Agatston score was >100. Cross-sectional associations between race, CIMT and CAC were assessed using logistic regression models. RESULTS: Blacks had greater CIMT (mean difference 0.033 mm, 95 % CI 0.005-0.06 mm; p = 0.02) and 1.5-fold (95 % CI 1.0-2.3) higher odds of having significant CIMT than Whites. Blacks had less CAC than Whites (mean Agatston score difference 66, 11-122; p = 0.02) and 50 % lower odds of a significant CAC score compared with Whites (0.5 0.3-0.7). These associations were virtually unchanged after adjustment for CVD risk factors. Of the novel CVD risk markers assessed, small-dense low-density lipoprotein was independently associated with increased odds of significant CIMT, with the association being similar among Blacks and Whites (odds ratio 95 % CI: 1.7 1.2-2.5 and 1.4 1.0-1.8 per 1-SD higher level, respectively). Interleukin-6 was significantly associated with CAC among Blacks (1.4 1.0-2.0). CONCLUSION: Black race is independently associated with greater CIMT but less CAC than White race. CVD risk stratification strategies that incorporate these measures of subclinical atherosclerosis should consider race-specific algorithms.
Erqou et al. (Thu,) conducted a cross-sectional in Subclinical atherosclerosis (n=1,245). Black race vs. White race was evaluated on Significant coronary artery calcium (Agatston score >100) (OR 0.5, 95% CI 0.3-0.7). Black race was independently associated with 1.5-fold higher odds of significant carotid intima media thickness and 50% lower odds of significant coronary artery calcium compared to White race.
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