INCLUSive: INtegrated Clustering, Upstream sequence retrieval and motif Sampling

Abstract Summary: INCLUSive allows automatic multistep analysis of microarray data (clustering and motif finding). The clustering algorithm (adaptive quality-based clustering) groups together genes with highly similar expression profiles. The upstream sequences of the genes belonging to a cluster are automatically retrieved from GenBank and can be fed directly into Motif Sampler, a Gibbs sampling algorithm that retrieves statistically over-represented motifs in sets of sequences, in this case upstream regions of co-expressed genes. Availability: For academic purposes at http://www.esat.kuleuven.ac.be/~dna/BioI/Software.html Contact: Gert.Thijs@esat.kuleuven.ac.be * To whom correspondence should be addressed. Email: Kathleen.Marchal@esat.kuleuven.ac.be.