Prescription of potentially harmful drugs in elderly patients with HFrEF was associated with an increased risk of readmission (HR 1.14; 95% CI 1.05-1.23; P<0.001).
Cohort (n=8,993)
Yes
Does the prescription of potentially harmful drugs increase the risk of readmission and mortality in elderly patients with HFrEF?
Prescription of potentially harmful drugs, particularly calcium channel blockers, remains frequent in elderly HFrEF patients and is associated with a significantly increased risk of hospital readmission.
Hazard Ratio: 1.14 (95% CI 1.05–1.23)
p-value: p=< 0.001
AIMS: This study aimed to evaluate the prescription frequency of potentially harmful prescription drugs as defined in current heart failure guidelines among elderly patients with a diagnosis of heart failure with reduced ejection fraction and their association with clinical outcomes. METHODS AND RESULTS: We used the Centers for Medicare 95% confidence interval 1.05-1.23, P < 0.001). Among drug subgroups, only calcium channel blockers were associated with an increased risk of readmission (hazard ratio 1.225; 95% confidence interval 1.085-1.382, P = 0.0011). CONCLUSIONS: In elderly patients discharged with a primary diagnosis of heart failure with reduced ejection fraction on guideline-directed medical therapy, prescription of a potentially harmful drug was frequent. Calcium channel blockers were associated with an increased risk of readmission.
Álvarez et al. (Sun,) conducted a cohort in Heart failure with reduced ejection fraction (n=8,993). Potentially harmful prescription drugs vs. No potentially harmful prescription drugs was evaluated on Readmission (HR 1.14, 95% CI 1.05-1.23, p=< 0.001). Prescription of potentially harmful drugs in elderly patients with HFrEF was associated with an increased risk of readmission (HR 1.14; 95% CI 1.05-1.23; P<0.001).
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