Patients with ARVD/C had significantly higher CRP levels compared to those with idiopathic RVOT tachycardia (3.5 vs 1.1 mg/l, P=0.0004), with levels peaking within 24 hours of a VT event.
Case-Control (n=91)
Are C-reactive protein levels elevated in patients with ARVD/C compared to idiopathic RVOT tachycardia, and do they correlate with recent ventricular tachycardia?
CRP levels are elevated in ARVD/C compared to idiopathic RVOT tachycardia and peak within 24 hours of a ventricular tachycardia event, suggesting an active inflammatory process.
Absolute Event Rate: 3.5% vs 1.1%
p-value: p=0.0004
Background. The relationship between C-reactive protein (CRP) elevation and ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is unclear. Methods and Results. In 91 consecutive patients with either ARVD/C with or without VT (cases) or idiopathic right ventricular outflow tract (RVOT) tachycardia (controls), blood sampling were taken to determine CRP levels. In ARVD/C patients with VT, we analyzed the association between VT occurrences and CRP level. Sixty patients had ARVD/C, and 31 had idiopathic RVOT VT. Patients with ARVD/C had a significant higher level of CRP compared to those with RVOT VT (3.5 ± 4.9 versus 1.1 ± 1.2 mg/l, P = .0004). In ARVD/C group, 77%, (n = 46) patients experienced VT. Of these, 37% (n = 17) underwent blood testing for CRP within 24 h after the onset of VT and the remaining 63% (n = 29) after 24 h of VT reduction. CRP level was similar in ARVD/C patients with or without documented VT (3.6 ± 5.1 mg/l versus 3.1 ± 4.1 mg/l, P = .372). However, in patients with ARVD/C and documented VT, CRP was significantly higher when measured within 24 hours following VT in comparison to that level when measured after 24 h (4.9 ± 6.2 mg/l versus 3.0 ± 4.4 mg/l, P = .049). Conclusion. Inflammatory state is an active process in patients with ARVD/C. Moreover, there is a higher level of CRP in patients soon after ventricular tachycardia, and this probably tends to decrease after the event.
Bonny et al. (Fri,) conducted a case-control in Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) (n=91). Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) vs. Idiopathic right ventricular outflow tract (RVOT) tachycardia was evaluated on C-reactive protein (CRP) levels (p=0.0004). Patients with ARVD/C had significantly higher CRP levels compared to those with idiopathic RVOT tachycardia (3.5 vs 1.1 mg/l, P=0.0004), with levels peaking within 24 hours of a VT event.