In Silico Molecular Docking Analysis and Adme Profiling of the Siddha Herbal Preparation- Sennaiuruvi Parpam Against Gastric Ulcer

Background and Objective: Siddha, one of the traditional systems of medicine practiced in India, is known for its unique approaches towards prevention, diagnosis as well as treatment of every disease. Ample literary evidence on medicinal formulations are found in Siddha literatures whose scientific validation is still partial. Gastric Ulcer is a common disease which is mentioned in Siddha as “Kunmam”, and is defined as a distinct breach in the mucosa of the gastrointestinal tract as a result of caustic effects of acid and pepsin in the lumen as defined by WHO. About 5 to 10 % of the world population are affected by Gastric ulcer. A strong scientific approach towards treatment perspectives are needed since the disease affects both physical and social-well being of the individuals. Many Siddha formulations for Kunmam are mentioned in literatures. One among them is the “Sennaiuruvi Parpam” mentioned in "Agathiyar 2000". A proper scientific validation of this formulation could pave the way for evidence based medicine, which is the foundation of scientific community. Materials and Methods: Preliminary Molecular Docking study through computational analysis was done with the Auto Dock tool to study the efficacy and ADME profiling were done for Sennaiuruvi Parpam against Gastric Ulcer. The binding action of major phytoconstituents of the drugs in Sennaiuruvi Parpam against various targets were documented. Results and Discussion: Most of the phytochemicals present in the drugs of Sennaiuruvi Parpam shows significant binding capacities against the targets like Proton pump inhibitor and COX-2. Hence it may be considered for the treatment and management of Gastric Ulcer. Conclusion: The Siddha herbal preparation "Sennaiuruvi Parpam " posses inherent action against Gastric Ulcer by binding with various targets was concluded by the present study.