Patient-specific non-Newtonian blood viscosity models yielded significantly different carotid wall shear stress predictions compared to four standard viscosity models.
Does the use of patient-specific non-Newtonian blood viscosity models significantly alter arterial wall shear stress predictions compared to generalized viscosity models in healthy volunteers?
Patient-specific non-Newtonian blood viscosity models yield significantly different wall shear stress predictions compared to generalized models, suggesting they are necessary for reliable physiological hemodynamic simulations.
Blood flow simulations can identify arterial regions that are vulnerable to atherosclerotic or thrombotic evolution. To accurately define vulnerable arterial regions, hemodynamic parameters such as arterial geometry, blood flow velocity and blood viscosity (BV) must be measured individually. However, previous numerical studies have largely employed either a single representative value or simply used a nonspecific curve of non-Newtonian characteristics of BV. This study aimed to evaluate whether various BV models could produce similar arterial wall shear stress (WSS) results. We performed a blood flow simulation in carotid arteries obtained from time-of-flight magnetic resonance (TOF MR) angiography using the hemodynamic characteristics of subjects via carotid duplex ultrasonography. The BV models were categorized into the following five types: patient-specific non-Newtonian BV (model 1), representative non-Newtonian BV based on the Carreau model (BV model 2), Newtonian BV measured at a specific shear rate of 300Formula: see textFormula: see text (BV model 3), Newtonian BV obtained from a hematocrit-based equation (BV model 4) and a representative Newtonian BV of 4Formula: see textcP (BV model 5). In total, 20 carotid arteries from 20 healthy volunteers (mean age Formula: see text SD of Formula: see text years; 50% women) were examined. Compared with the mean values of carotid WSS in BV model 1 as the reference model, the other four models showed significant differences in both genders for all carotid segments. To obtain reliable physiological WSS results, patient-specific non-Newtonian BV should be carefully employed.
Lee et al. (Sun,) conducted a other in Healthy (n=20). Patient-specific non-Newtonian blood viscosity model vs. Four other standard blood viscosity models was evaluated on Carotid arterial wall shear stress (WSS). Patient-specific non-Newtonian blood viscosity models yielded significantly different carotid wall shear stress predictions compared to four standard viscosity models.
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