Sacubitril/valsartan therapy in HFrEF was associated with significant improvements in left atrial and ventricular strain and strain rate after 6 months, particularly among patients in sinus rhythm.
Observational (n=35)
Does sacubitril/valsartan improve left atrial and ventricular strain and strain rate in patients with HFrEF?
Sacubitril/valsartan therapy significantly improves subclinical echocardiographic markers of left atrial and ventricular function (strain and strain rate) in patients with HFrEF, particularly those in sinus rhythm.
BACKGROUND: Data on the impact of sacubitril/valsartan (SV) therapy on phasic left atrial (LA) and left ventricular (LV) strain in heart failure with reduced ejection fraction (HFrEF) are limited. The aim of this study was to evaluate changes in two-dimensional speckle tracking (2D-STE) parameters with SV therapy in HFrEF patients. METHODS: Prospective evaluation of HFrEF patients receiving optimized medical therapy. Two-dimensional speckle tracking (2D-STE) parameters were assessed at baseline and after 6 months of SV therapy. LA strain and strain rate (SR) in reservoir, conduit, and contraction phases were compared with LV longitudinal, radial, and circumferential strain and SR and stratified according to heart rhythm and HFrEF etiology. RESULTS: A total of 35 patients completed the 6-month follow-up, with a mean age of 59 ± 11 years, 40% in atrial fibrillation, 43% with ischemic etiology, and LVEF of 29 ± 6%. There were significant improvements in LA reservoir, conduit, and contractile strain and SR following SV therapy, particularly among patients in sinus rhythm. There were significant improvements in longitudinal, radial, and circumferential LV function indices. CONCLUSION: SV therapy in HFrEF was associated with improved longitudinal, radial, and circumferential function, particularly among patients in sinus rhythm. These findings can provide insights into the mechanisms underlying the improvement of cardiac function and help assess subclinical responses to the treatment.
Bras et al. (Wed,) conducted a observational in Heart failure with reduced ejection fraction (HFrEF) (n=35). Sacubitril/valsartan vs. Baseline was evaluated on Changes in two-dimensional speckle tracking (2D-STE) parameters including left atrial and left ventricular strain and strain rate. Sacubitril/valsartan therapy in HFrEF was associated with significant improvements in left atrial and ventricular strain and strain rate after 6 months, particularly among patients in sinus rhythm.