2889-LB: Continuous Glucose Monitoring Profile of Older Men without Diabetes

Introduction and Objective: Use of continuous glucose monitoring (CGM) and glucose biosensors are increasing in people without diabetes to support health and wellness. However, there is currently limited data on the CGM profile of older adults without diabetes. This study examined the CGM profile of older men without diabetes over 24 hours. Methods: Thirty-three older men without diabetes age: 67±4 years; BMI: 25.4±2.5 kg/m2; fasting plasma glucose: 103±13 mg/dL (5.7±0.7 mmol/L); HbA1c 6.5% (48 mmol/mol) resided in a metabolic chamber under highly controlled conditions for 24 hours. Participants were fed an isocaloric diet (~%45% carbohydrate, ~20% protein, ~35% fat) and performed three bouts of 30 min step exercise at 75 steps/min (~6,750 steps/24 hours). Participants wore a CGM for the entire 24-hour period. Several CGM metrics were calculated (Table). Results: Participants were in euglycemia 54-120 mg/dL (3.0-6.6 mmol/L) 80.9±12.6% of the time, in time tight range TITR; 70-140 mg/dL (3.9-7.8 mmol/L) 89.7±8.1% of the time, and were above 140 mg/dL (7.8 mmol/L) 7.4±6.6% of the time. Mean glucose was 100±11 mg/dL (5.6±0.6 mmol/L). Other CGM metrics can be seen in Table. Conclusion: The present study provides normative data on the CGM profile of older men without diabetes under highly controlled conditions over 24 hours. This data may be informative as a benchmark for future studies in older adults without diabetes. Disclosure C. Griffen: Employee; Current; Dexcom, Inc. D. Renshaw: None. M. Duncan: None. M.O. Weickert: None. J. Hattersley: None.