Integral systolic S' wave tricuspid annular velocity (AUC 0.922) and RV free wall longitudinal strain (AUC 0.913) had the best prognostic performance for predicting adverse heart failure outcomes.
Cohort (n=79)
Do echocardiographic parameters predict adverse outcomes better than CMR or ERV in patients undergoing right ventricular function assessment?
Echocardiographic parameters, particularly integral systolic S' wave tricuspid annular velocity and RV free wall longitudinal strain, demonstrate superior prognostic performance for adverse heart failure outcomes compared to CMR and ERV.
Effect estimate: AUC 0.922
p-value: p=<0.001
BACKGROUND: Right ventricular (RV) function is a powerful independent predictor of adverse heart failure outcomes. The aim of this study was to compare the predictive value of main RV systolic imaging parameters for outcome. METHODS: Seventy-nine patients underwent comprehensive cardiovascular imaging modalities including transthoracic echocardiography, cardiac magnetic resonance (CMR) imaging, and tomographic equilibrium radionuclide ventriculography (ERV) for the assessment of RV function. The composite primary endpoint (CPE) was defined by the occurrence of death, heart transplantation, implantation of a left ventricular assist device, or new-onset acute heart failure. RESULTS: During a mean follow-up of 13 ± 9 months, 15 (19%) patients reached the CPE. The areas under the receiver operator characteristic curves for the prediction of the CPE were 0.922 (P < .001), 0.913 (P < .001), 0.906 (P < .001), 0.849 (P = .002), 0.837 (P = .003), 0.799 (P = .009), 0.792 (P = .011), 0.753 (P = .026), 0.720 (P = .053), and 0.608 (P = .346) for integral systolic S' wave tricuspid annular velocity, RV free wall longitudinal strain (RVFWLS), RV fractional area change, tricuspid annular plane systolic excursion, RV ejection fraction (RVEF) by CMR using the 4-chamber slices, peak systolic S' wave tricuspid annular velocity, RVEF by CMR using short-axis slices, RVEF by ERV, RV myocardial performance index, and RV myocardial acceleration during isovolumic contraction, respectively. CONCLUSION: Echocardiographic parameters, and particularly integral systolic S' wave tricuspid annular velocity and RVFWLS, have the best prognostic performance.
Cazalbou et al. (Mon,) conducted a cohort in Heart failure (n=79). Right ventricular systolic imaging parameters was evaluated on Composite primary endpoint defined by the occurrence of death, heart transplantation, implantation of a left ventricular assist device, or new-onset acute heart failure (AUC 0.922, p=<0.001). Integral systolic S' wave tricuspid annular velocity (AUC 0.922) and RV free wall longitudinal strain (AUC 0.913) had the best prognostic performance for predicting adverse heart failure outcomes.