Three-Dimensional Functionalization of Macrocycles: Porphyrin and Polycyclic Carbon Cage Hybrid

Key Points

• This research aims to create a hybrid macrocycle by integrating porphyrins with a chiral carbon cage to explore its structural characteristics.
• Developed a three-dimensional functionalization strategy for porphyrins.
• Created a hybrid architecture combining porphyrins with a bisnorditwistane cage.
• Characterized the macrocycle's protonation behavior.
• The macrocycle demonstrates a well-defined two-step protonation behavior.
• Integration of a rigid chiral cage with a planar triheterocyclic fragment is achieved.