High computed tomography-derived iliofemoral access-site calcification volume was independently associated with increased 3-year all-cause mortality after TAVI (HR 1.24 per standard deviation increase).
Cohort (n=1,067)
No
Does high iliofemoral access-site calcification volume predict increased mortality in patients undergoing TAVI?
CT-derived iliofemoral access-site calcification volume provides incremental prognostic information for mid- and long-term mortality after TAVI, reflecting systemic disease burden rather than just procedural risk.
Hazard Ratio: 1.24 (95% CI 1.11–1.38)
Absolute Event Rate: 34.3% vs 22.3%
p-value: p=<0.01
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly performed in patients at low and intermediate risk, emphasizing the need for accurate long-term risk stratification. Although iliofemoral calcification influences procedural planning, its prognostic relevance beyond peri-procedural complications remains uncertain. OBJECTIVES: To evaluate the prognostic value of quantitatively assessed iliofemoral access-site calcification (IASC) for outcomes after TAVI. METHODS: The study included 1067 patients undergoing TAVI. Pre-procedural computed tomography (CT) was used to quantify IASC-volume along the transfemoral access route. Patients were stratified according to the median IASC-volume, and outcomes were compared using propensity score matching (PSM). The primary endpoint was all-cause mortality at 1, 3, and 5 years. Secondary endpoints included peri-procedural complications at 30 days. RESULTS: . Patients with high IASC-volume had higher prevalence of vascular comorbidities and increased risk scores. IASC-volume was not associated with vascular or bleeding complications. The overall 1-year mortality was 11.7% and did not differ between patients with low and high IASC-volume (10.5% vs. 12.8%; p = 0.20). In contrast, patients with high IASC-volume experienced significantly higher mortality at 3 years (34.3% vs. 22.3%; p < 0.01) and 5 years (42.2% vs. 28.7%; p < 0.01). These findings remained consistent after PSM. In multivariable analysis, IASC-volume was independently associated with long-term mortality (HR 1.24, 95% CI 1.11-1.38; p < 0.01). CONCLUSION: CT-derived IASC-volume is associated with mid- and long-term mortality after TAVI, without affecting short-term or procedural outcomes. These findings suggest that IASC-volume reflects systemic disease burden and may provide incremental prognostic information beyond established risk scores.
Vij et al. (Thu,) conducted a cohort in Severe symptomatic aortic stenosis (n=1,067). High iliofemoral access-site calcification volume vs. Low iliofemoral access-site calcification volume was evaluated on 3-year all-cause mortality (HR 1.24, 95% CI 1.11-1.38, p=<0.01). High computed tomography-derived iliofemoral access-site calcification volume was independently associated with increased 3-year all-cause mortality after TAVI (HR 1.24 per standard deviation increase).