BDNF and Beyond: Unlocking the Therapeutic Potential of Neurotrophic Pathways in Depression (P6-13.010)

Key Points

• This research aims to connect neuroanatomical and molecular factors in major depressive disorder with neuroplasticity issues and treatment mechanisms.
• Synthesize evidence from neuroanatomical and molecular studies.
• Evaluate pharmacologic and non-pharmacologic interventions.
• Focus on treatments that restore plasticity through neurotrophic mechanisms.
• Evidence supports the link between major depressive disorder and impaired neuroplasticity.
• Both pharmacologic and non-pharmacologic treatments show potential in restoring plasticity.
• Neurotrophic mechanisms are critical in the therapeutic effects of these treatments.