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This research aims to develop a new method for mapping m6A modifications at a single-base level in the transcriptome.

July 3, 2019Science Advances417 citationsOpen Access

Single-base mapping of m 6 A by an antibody-independent method

This research aims to develop a new method for mapping m6A modifications at a single-base level in the transcriptome.
Introduced a novel antibody-independent technique for m6A mapping.
Conducted a transcriptome-wide analysis to assess m6A site conservation.
Generated reliable m6A maps demonstrating high precision at a single-base resolution.
Revealed conserved m6A site patterns across different mammalian species.

A new transcriptome-wide method produces reliable m 6 A maps at single-base resolution and reveals site conservation in mammals.

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