Low-grade inflammation localized in vascular tissue is recognized as an important contributor to the pathophysiology of hypertension and the development of cardiovascular diseases.
Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.
Savoia et al. (Sat,) conducted a review in Hypertension. Low-grade inflammation localized in vascular tissue is recognized as an important contributor to the pathophysiology of hypertension and the development of cardiovascular diseases.