ASBMB Learning Objectives (https://www.asbmb.org/education/core-concept-teaching-strategies/foundational-concepts/structure-function) 2. Structure is determined by several factors Students should be able to recognize the repeating units in biological macromolecules and be able to discuss the structural impacts of the covalent and noncovalent interactions involved (Introductory). Students should be able to use various bioinformatics approaches to analyze macromolecular primary sequence and structure (Intermediate). 3. Structure and function are related Students should be able to use mechanistic reasoning to explain how an enzyme or ribozyme catalyzes a particular reaction (Introductory). 4. Macromolecular interactions Students should be able to discuss the interactions between a variety of biological molecules (including proteins, nucleic acids, lipids, carbohydrates and small organics, etc.) and describe how these interactions impact specificity or affinity leading to changes in biological function (Intermediate). Students should be able to predict the effects of either mutation or ligand structural change on the affinity of binding and design appropriate experiments to test their predictions (Upper).
Gadd et al. (Wed,) studied this question.