Chronic kidney disease in cancer patients was associated with increased cancer-specific mortality (HR 1.75; 95% CI 1.32-2.32; p<0.001 for eGFR <30 ml/min/1.73 m2).
Cohort (n=8,223)
Does the presence of chronic kidney disease increase cancer-specific mortality in cancer patients?
Chronic kidney disease is an independent predictor of increased cancer-specific mortality in patients with malignant disease.
Hazard Ratio: 1.75 (95% CI 1.32–2.32)
p-value: p=<0.001
BACKGROUND/AIMS: The effects of chronic kidney disease (CKD) on the risk of death for patients with malignant disease are uncertain. The aim of this study was to determine the association between the presence of CKD and mortality in cancer patients. METHOD: We retrospectively reviewed the cases of 8,223 cancer patients with one or more serum creatinine measurements from January 1, 2000 to December 31, 2004. The key outcome was cancer-specific mortality within the follow-up period. The cumulative incidence rate for death from cancer was estimated using methods of competing risks survival analysis. Cox proportional-hazards regression with the use of Fine and Gray's proportional-hazards model were evaluated in multiple analyses. RESULTS: CKD was associated with an increased risk of death in cancer patients. The adjusted hazard ratios were 1.12 for patients with an estimated glomerular filtration rate (eGFR) of 30-59 ml/min/1.73 m(2) (95% confidence interval 1.01-1.26, p = 0.04) and 1.75 for patients with an eGFR <30 ml/min/1.73 m(2) (95% confidence interval 1.32-2.32, p < 0.001). CONCLUSIONS: CKD should be considered a risk factor for survival among patients with cancer.
Na et al. (Sat,) conducted a cohort in Cancer (n=8,223). Chronic kidney disease (CKD) vs. Normal renal function (implied) was evaluated on Cancer-specific mortality (HR 1.75, 95% CI 1.32-2.32, p=<0.001). Chronic kidney disease in cancer patients was associated with increased cancer-specific mortality (HR 1.75; 95% CI 1.32-2.32; p<0.001 for eGFR <30 ml/min/1.73 m2).