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The existence of a Na(+)-dependent mechanism for Ca(2+) efflux from isolated rat liver mitochondria was confirmed. The activity of this system is decreased by 60% in mitochondria isolated from perfused livers. The Na(+)-dependent activity is fully restored by infusion of either 1mum-adrenaline or 1mum-isoprenaline, but the alpha-adrenergic agonist phenylephrine is ineffective.
Goldstone et al. (Thu,) studied this question.
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