High circulating Angiopoietin-2 levels were significantly associated with left ventricular hypertrophy (adjusted OR 2.68) in patients with stage 3-5 chronic kidney disease.
Observational (n=270)
No
Are circulating levels of Angpt2, Angpt1, and VEGF-A associated with subclinical cardiovascular disease in pre-dialysis stage 3-5 CKD patients?
High Angpt2 and low Angpt1 levels are associated with abnormal cardiac structure in patients with stage 3-5 chronic kidney disease, suggesting a role for angiopoietins in cardiovascular burden.
Odds Ratio: 2.68 (95% CI 1.15–6.2)
Absolute Event Rate: 79.1% vs 55.2%
Angiopoietins (Angpt) and vascular endothelial growth factor (VEGF) have been associated with cardiovascular disease. The study enrolled 270 pre-dialysis stage 3-5 CKD patients to assess the link between circulating Angpt2, Angpt1 and VEGF-A and subclinical measures of cardiovascular structure and function. Serum markers of angiogenesis were measured using commercial enzyme-linked immunosorbent assays. Cardiac structure and function were examined by echocardiography. Brachial-ankle pulse wave velocity (baPWV) was measured by the ankle-brachial index. The adjusted mean of left ventricular mass index (LVMI) was 2.05 in patients of Angpt2 quartile 4 and 1.99 in those of Angpt2 quartile 1 (P = 0.04). Angpt2 was significantly associated with LV hypertrophy (LVH) (Angpt2 quartile 4 compared with Angpt2 quartile 1: adjusted OR: 2.68, 95% CI: 1.15-6.20). Angpt1 was negatively correlated with left atrial diameter (adjusted mean of LAD: 3.59 in Angpt1 quartile 4, 3.92 in Angpt1 quartile 1, P = 0.03). A positive and significant correlation was found between Angpt2 level and baPWV in spearman's correlation, but not in adjusted model. In conclusion, high Angpt2 and low Angpt1 levels were positively associated with abnormal cardiac structure in stages 3-5 CKD patients, which is compatible with the viewpoint that angiopoietins participates in cardiovascular burdens.
Tsai et al. (Mon,) conducted a observational in Chronic Kidney Disease (stages 3-5) (n=270). High circulating Angiopoietin-2 (Angpt2) levels vs. Low circulating Angiopoietin-2 (Angpt2) levels was evaluated on Left ventricular hypertrophy (LVH) (OR 2.68, 95% CI 1.15-6.20). High circulating Angiopoietin-2 levels were significantly associated with left ventricular hypertrophy (adjusted OR 2.68) in patients with stage 3-5 chronic kidney disease.
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