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January 1, 2014Cleveland Clinic Journal of Medicine29 citationsOpen Access

Albuminuria: When urine predicts kidney and cardiovascular disease

RSReejis StephenSJStacey E. JollyJNJoseph V. Nally

Key Result

Albuminuria is independently associated with a higher risk of death, cardiovascular events, heart failure, stroke, and progression of chronic kidney disease.

PICO

P
Population
Albuminuria
E
Exposure / Comparator
Albuminuria

Limitations

  • Evidence is limited in favor of routinely screening for albuminuria in the general population.
  • Methods of measuring albumin and total protein vary considerably in their precision and accuracy.
  • It remains unclear whether the cardiovascular benefits of ACE inhibitors or ARBs are a direct result of reducing albuminuria or treating other risk factors.

Abstract

Albuminuria is common. Traditionally considered a precursor to diabetic nephropathy, it has now been directly linked to adverse cardiovascular outcomes and death, independent of other risk factors. In this review, we compare the measures of albuminuria, examine the evidence linking it to renal failure, cardiovascular disease, and death, and provide recommendations for its testing and management.

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Cite This Study

Stephen et al. (2014) conducted a review in Albuminuria. Albuminuria was evaluated. Albuminuria is independently associated with a higher risk of death, cardiovascular events, heart failure, stroke, and progression of chronic kidney disease.

synapsesocial.com/papers/6a61ac9b0579a17fd4c91b1fhttps://doi.org/10.3949/ccjm.81a.13040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Albuminuria: pathophysiology, Epidemiology and Clinical Relevance of an Emerging Marker for Cardiovascular Disease2007 · 26 citations
  2. 2Interest of albuminuria in nephrology, diabetology and as a marker of cardiovascular risk2019 · 15 citations
  3. 3Proteinuria in Diabetes2010 · 70 citations
  4. 4Monitoring Kidney Function and Albuminuria in Patients With Diabetes2011 · 46 citations
  5. 5Albuminuria: Its Importance in Disease Detection2007 · 13 citations