Impaired left ventricular diastolic function in CAD patients is strongly associated with increased plasma concentrations of leptin, resistin, IL-6, and adiponectin.
Cross-Sectional (n=55)
No
In men with coronary artery disease, left ventricular diastolic dysfunction is strongly associated with circulating adipokines, whereas obesity and type 2 diabetes have a limited effect on adipokine expression in epicardial and subcutaneous adipose tissue.
BACKGROUND: Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contribution to systemic concentrations of adipokines. However, proximity of EAT to cardiac muscle and coronary arteries allows cells and proteins to penetrate between tissues. It is hypothesized that overexpression of proinflammatory cytokines in EAT plays an important role in pathophysiology of the heart. The aim of the study was to analyze the relationship between echocardiographic heart parameters and adipokines in plasma, epicardial, and subcutaneous fat in patients with obesity and type 2 diabetes mellitus (T2DM). Additionally, we evaluate proinflammatory properties of EAT by comparing that depot with subcutaneous adipose tissue. METHODS: The study included 55 male individuals diagnosed with coronary artery disease (CAD) who underwent planned coronary artery bypass graft. Plasma concentrations of leptin, adiponectin, resistin, visfatin, apelin, IL-6, and TNF-α, as well as their mRNA and protein expressions in EAT and subcutaneous adipose tissue (SAT) were determined. RESULTS: Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT. Impaired left ventricular (LV) diastolic function was associated with increased plasma concentrations of leptin, resistin, IL-6, and adiponectin, as well as with increased expressions of resistin, apelin, and adiponectin in SAT, and leptin in EAT. CONCLUSIONS: Obesity and T2DM in individuals with CAD have a limited effect on adipokines. Expression of adipokines in EAT and SAT is linked to certain heart parameters, however diastolic dysfunction of the LV is strongly associated with circulating adipokines.
Toczyłowski et al. (2019) conducted a cross-sectional in Coronary Artery Disease (n=55). Adipokine levels and tissue expression vs. Reference adipokine levels was evaluated on Association between adipokine expression/concentration and echocardiographic heart parameters. Impaired left ventricular diastolic function in CAD patients is strongly associated with increased plasma concentrations of leptin, resistin, IL-6, and adiponectin.