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January 11, 2003Organic Letters239 citations

Regioselective Palladium-Catalyzed Arylation of 3-Carboalkoxy Furan and Thiophene

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BGBobby GloverKHKimberly A. HarveyBLBing Liu

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Abstract

reaction: see text The regioselective palladium(0)-catalyzed arylation of 3-furoate and 3-thiophenecarboxylate esters with aryl bromides is described. Conditions were developed that allow for the selective synthesis of either 2-aryl or 5-aryl products.

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Glover et al. (2003) studied this question.

synapsesocial.com/papers/6a7d19a5a7b865a28f749237https://doi.org/10.1021/ol027266q
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