Antimicrobial resistance (AMR) has become a global health concern, sometimes called the "silent pandemic" since it slowly but surely harms public health, clinical outcomes, and economic stability. The inappropriate use of antibiotics in medicine, farming, and animal husbandry, along with a lack of good regulatory monitoring and pollution of the environment, has sped up the evolution and spread of microbes that are resistant to them. This review looks at the many factors that contribute to AMR, including its molecular processes, environmental causes, clinical burden, and global spread. Increased resistance to normal treatments has made bacteria, including Escherichia coli, Klebsiella pneumoniae, MRSA, and multidrug-resistant Mycobacterium tuberculosis more common, which has led to higher rates of illness, death, and healthcare expenses. We did a thorough analysis of the literature using peer-reviewed sources to look at recent data on trends in resistance, important resistance genes, and how well current tactics to reduce resistance work. The results show that there are big holes in AMR surveillance, diagnostic tools, and the antibiotic research pipeline. Resistance genes are also common in natural environments, which makes containment even harder. Antimicrobial stewardship initiatives and global action plans have made some headway, but to really deal with the way AMR affects people, animals, and the environment, we need a united, One Health strategy. The assessment ends by stressing the importance of coordinated action around the world, new treatments, quick tests, and strong policy frameworks. AMR poses a significant threat to the sustainability of modern medical practices and infection control if left unaddressed and bring about a post-antibiotic future in which even small illnesses could become deadly if nothing is done right away.
Mami et al. (2025) studied this question.