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Synapse
August 2, 20250 citations

Figure S5 from Single-Cell Analysis of Posttranslational Modifications Identifies Immunosuppressive Macrophage Subtypes in the HBV-Positive Hepatocellular Carcinoma Microenvironment

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HZHuakan ZhaoRRRan RenXZXi Zhang

Key Points

  • MAIN FINDING: Immunosuppressive macrophage subtypes were identified in HBV-positive hepatocellular carcinoma.
  • KEY EVIDENCE: Subtypes were distinguished using posttranslational modification profiles of p-HSP27, p-STAT1, and p-TRIM28.
  • APPROACH: The research utilized single-cell analysis to characterize macrophage subtypes within the tumor microenvironment.
  • SIGNIFICANCE: Understanding these subtypes could lead to new therapeutic strategies in hepatocellular carcinoma treatment.

Abstract

Subtyping M2 macrophages based on profiles of p-HSP27, p-STAT1, and p-TRIM28.

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Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0245https://doi.org/10.1158/2326-6066.29760559
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