The Schiff base ligand was prepared by reacting Diacetyl monoxime with O-phenylene di-amine. Then react the resulting compound from the first step with 4-aminoantipyrine to produce the ligand (2E,3E)-3-(((Z)-4-amino-1,5-dimethyi-2-phenyl-1,2-dihydro-3h-pyrazol-3-ylidene)amino)phenyl) imino) butan-2-one oxime.Then the step of preparing the complexes is by reacting with chlorides of the elements CuCl2.2H2O, CdCl2.2H2O,PdCl2and AgNO3. The complexes exhibited a metal ion-to-ligand ratio (M:L) of 1:1. The Cu(II) complex displayed an octahedral geometric shape, while the Ag(I) and Cd(II) complexes displayed tetrahedral geometric shapes. On the other hand, the Pd(II) complex displayed a square planar geometric shape. The structure of the compounds was confirmed through a series of spectroscopic measurements, including FTIR, 1H-NMR, 13C-NMR, UV-Vis, (C, H, N, S), FESEM, magnetic susceptibility, molar conductivity, and melting point. Assessing the biological efficacy of ligands and Ag(I) through antioxidant testing and anticancer testing is a multifaceted process and complex. It was found that it has good effectiveness against HL-60 leukemia and MCF-7 breast cancer cells, and it can be used as a medicine after being well studied.
Ashour et al. (2025) studied this question.