Background: Amlapitta, one of the most prevalent disorders of the Annavaha Strotas, is primarily caused by impaired Agni and vitiated Pachaka Pitta, leading to symptoms like Avipaka (indigestion), Amlodgara (sour/bitter belching), Hrid-Kantha Daha (burning sensation in chest and throat), and Aruchi (anorexia). Factors like improper diet, lifestyle habits, stress, and incompatible food combinations contribute significantly to its pathogenesis. Objective: To systematically review various clinical studies and research dissertations exploring the effectiveness of Shodhana and Shamana Chikitsa in the management of Amlapitta. Methods: This review analyzed 19 dissertations from the Ayurvedic Research Database (ARD, 7th Edition, 2001–2018) sourced from various departments like Kayachikitsa, Panchakarma, and Dravyaguna. Studies included both conceptual and clinical approaches, with interventions ranging from classical Ayurvedic formulations to Panchakarma therapies like Virechana. Results: Most studies showed that integrative approaches combining Shodhana and Shamana Chikitsa yielded more significant symptomatic relief than standalone treatments. However, there was a lack of standardized modern diagnostic tools and uniform methodologies. Several formulations such as Dashanga Vati, Guduchyadi Ghana Vati, and Avipattikara Churna showed promising results in reducing cardinal symptoms of Amlapitta. Some trials also emphasized the role of Dosha predominance in treatment selection.
Patel et al. (2025) studied this question.