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This is a Observational study (also classified as: In Vitro Study).

August 22, 2025FEBS JournalOpen Access

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

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Experimental evidence reveals a heteromeric CPT complex mediates dolichol biosynthesis in Paramecium, suggesting specific targets for therapies.

Loss of POC1 or CPT1a leads to reduced dolichol production and significant glycoprotein loss, causing cell death.
CPT1a and CPT1b show high sequence similarity to other eukaryotic cis-prenyltransferases, providing insight into their evolution.
A multidisciplinary approach identified a unique CPT-accessory subunit, POC1, crucial for polyprenyl synthesis in this model organism.
Distinctive features of protozoan CPT-accessory subunits could uncover potential antiparasitic therapy targets.

Onyśk et al. (2025) studied this question.

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August 22, 2025FEBS JournalOpen Access

View Full Paper

Ask AI

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Authors

Experimental evidence reveals a heteromeric CPT complex mediates dolichol biosynthesis in Paramecium, suggesting specific targets for therapies.

Loss of POC1 or CPT1a leads to reduced dolichol production and significant glycoprotein loss, causing cell death.
CPT1a and CPT1b show high sequence similarity to other eukaryotic cis-prenyltransferases, providing insight into their evolution.
A multidisciplinary approach identified a unique CPT-accessory subunit, POC1, crucial for polyprenyl synthesis in this model organism.
Distinctive features of protozoan CPT-accessory subunits could uncover potential antiparasitic therapy targets.

Onyśk et al. (2025) studied this question.

View Full Paper

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