Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brain
Analysis reveals lipid-laden endothelial cells show increased inflammation and blood-brain barrier impairment in aging, suggesting new therapeutic targets.
Key Points
Lipid accumulation in endothelial cells is linked to blood-brain barrier dysfunction and increased inflammation.
Aging leads to altered metabolic phenotypes in endothelial cells, including reduced glycolysis and impaired mitochondrial function.
Single-cell transcriptomic analysis shows structural and functional impairments in endothelial cells due to lipid dysregulation.
Understanding lipid-induced dysfunction in endothelial cells can inform new strategies to combat age-related brain diseases.