Heterogeneous Fe single-atom catalysis for C2–H amidation of pyridine/quinoline N-oxides: streamlined synthesis of pharmaceutical scaffolds

Key Points

• The novel catalytic method improves the efficiency of C2-H amidation in nitrogen-containing compounds, expanding synthetic possibilities.
• Using a nitrogen-doped carbon matrix, the strategy stabilizes atomic iron sites, enhancing catalyst performance for pharmaceutical applications.
• The heterogeneous system allows for direct amidation of pyridine and quinoline N-oxides, providing a streamlined approach for synthesizing complex scaffolds.
• This method may facilitate the development of new drugs by simplifying the synthesis of essential building blocks in pharmaceuticals.