Supplementary Figure 16. Comparison of gut microbiome profiles in MM patients from the first cohort at baseline (apheresis day) and 12 months post–CAR-T-cell infusion. (A) Principal coordinates analysis (PCA) of bacterial community composition at baseline (apheresis day) vs 12 months post CAR-T cell infusion microbiome in MM patients. (B) Variable importance in projection (VIP) scores from partial least square-discriminant analysis (PLS-DA) identifying the top 10 discriminating parameters from 16sRNA metagenomics. Scores plot of PLS-DA based on metagenomics of samples 12 months post-infusion (purple, n = 4) and at baseline (blue, n = 4) from paired patients. Colored dots illustrate individual samples. Axes are labeled with the first and second components and their respective percentages of explained variance.
Uribe‐Herranz et al. (2025) studied this question.