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September 10, 2025International Journal of Oncology0 citations

Retracted MicroRNA‑181a regulates epithelial‑mesenchymal transition by targeting PTEN in drug‑resistant lung adenocarcinoma cells

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HLHaihui LiPZPei ZhangXSXiaojin Sun

Key Points

  • Epithelial-mesenchymal transition is influenced by microRNA-181a targeting PTEN, which relates to drug resistance.
  • Evidence of data duplication was found in multiple figures, undermining confidence in published results.
  • Lung adenocarcinoma cells demonstrated altered migration and invasion patterns due to microRNA regulation.
  • The retraction highlights the importance of data integrity and ethical standards in cancer research.

Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the scratch wound and cell migration and invasion assay experiments shown in Fig. 2A and B and Fig. 5A‑C, a large number of data panels showed evidence of overlapping data, both within the same figure parts and comparing between figures. Similarly, evidence was also uncovered of data duplication comparing the cell microscopic images in Figs. 6A, 7B and 8B. Owing to the large number of data duplication events that have been identified in this paper, the Editor of International Journal of Oncology has decided that it should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. International Journal of Oncology 47: 1379‑1392, 2015; DOI: 10.3892/ijo.2015.3144.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb816https://doi.org/10.3892/ijo.2025.5784
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