The emergence of CRF80₀107 resulted from recombination between co-circulating CRF01AE and CRF07BC genotypes. To date, no secondary recombinants involving CRF80₀107 as a parental strain have been documented in public sequence databases. Here, we report the identification and characterization of a novel HIV-1 CRF80₀107/B recombinant form isolated from a treatment-naïve men who have sex with men (MSM) individual in Baoding City, Hebei Province, China. While phylogenetic analysis of the near-full-length genome revealed clustering with the CRF80₀107 lineage, Bootscan and similarity-mapping analyses (RIP 3. 0) identified a recombinant structure containing inserted B subtype fragments spanning the env, nef, and 3'LTR regions (HXB2: 7, 907-9, 342 nt). This represents the first documented CRF80₀107/B strain in the MSM population of northern China, highlighting the need for expanded molecular surveillance to track evolving HIV-1 diversity in this key population.
Zhang et al. (2025) studied this question.