Purpose: Ophthalmology, though fundamental, is often sidelined in modern medical curricula—despite its complex anatomy and the looming shortage of ophthalmologists. To reimagine how students engage with this vital field, we developed and evaluated an immersive, peer-led virtual reality (VR) simulation lab designed to enhance first-year medical students’ understanding, confidence, and enthusiasm for ophthalmology at Loyola University Chicago Stritch School of Medicine. Methods: Forty-two first-year students participated in a 1-hour session combining foundational didactics with experiential learning at 3 interactive VR stations. These featured the OcuSim app via Oculus headsets, stereoscopic EyeSim modules, and the iBench 3D ZSpace platform. Guided by senior students and residents, participantsexplored ocular anatomy, pathology, and neurovisual pathways in an immersive format. Pre- and post-session surveys and assessments captured changes in confidence, knowledge, and clinical reasoning. Statistical analysis utilized Wilcoxon signed-rank and McNemar chi-square tests. Results: The intervention yielded marked improvements across cognitive and affective domains. Confidence in labeling ocular anatomy rose from a mean of 2.7 to 3.5 (p < 0.01), and visual pathway comprehension improved from 2.3 to 3.3 (p < 0.01). Objective assessments confirmed gains in anatomical labeling and interpretation of neuro-ophthalmic deficits, including cranial nerve III palsies and Meyer’s loop lesions. Notably, 100% of students answered cranial nerve III-related questions correctly post-intervention, up from 78.6%. Feedback highlighted the lab’s novelty, relevance, and its capacity to make complex content intuitive and engaging. Conclusion: This student-led VR simulation lab transcends traditional teaching by blending clinical relevance with cutting-edge interactivity. It significantly boosts anatomical comprehension, clinical reasoning, and learner confidence—while igniting interest in an underserved specialty. As immersive technology becomes more accessible, this model offers a scalable blueprint for transforming medical education with impact and innovation.
Tajran et al. (2025) studied this question.